The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

Cancer, a disease that modern medicine has not fully understood and conquered, with its high incidence and mortality, deprives countless patients of health and even life.According to global cancer statistics, there were an estimated 19.3 million new cancer cases and nearly 10 million cancer deaths in 2020, with the age-standardized incidence and mo

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Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Abstract Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis).Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the intestine.It is unclear how changes in metabolite availability during gut inflammation im

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Preoperative portal vein embolization followed by right hepatectomy to treat a complex common bile duct injury in a 5-year-old child

Background Common bile duct injuries (CBDIs) remains a rare but serious complication in children undergoing MCT laparoscopic cholecystectomy (LC), with an incidence of 0.44%.In severe lesions, a major liver resection may be necessary as a definitive treatment.The current principles for safe hepatectomy are mainly focused on the liver parenchyma tha

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